Where are the target cells for calcitonin?

Where are the target cells for calcitonin?

bone
Calcitonin functions on targets cells primarily in bone and kidney. The actions of parathyroid hormone and calcitonin are antagonistic on bone resorption but synergistic on decreasing the renal tubular reabsorption of phosphorus.

How does calcitonin affect target cells?

In particular, calcitonin has the ability to decrease blood calcium levels at least in part by effects on two well-studied target organs: Bone: Calcitonin suppresses resorption of bone by inhibiting the activity of osteoclasts, a cell type that “digests” bone matrix, releasing calcium and phosphorus into blood.

What cells are affected by calcitonin?

Calcitonin reduces calcium levels in the blood by two main mechanisms: It inhibits the activity of osteoclasts, which are the cells responsible for breaking down bone. When bone is broken down, the calcium contained in the bone is released into the bloodstream.

What is the target tissue for calcitonin and how does it respond to the binding of this hormone?

Calcitonin is secreted in response to hypercalcemia and also to a calcium-rich meal. Calcitonin secretion increases during hypercalcemia, but the effects of calcitonin on normal calcium homeostasis are considered to be minor. The major target site for calcitonin is bone, where it inhibits osteoclastic bone resorption.

What are C cells?

Calcitonin. Parafollicular cells (C cells) scattered throughout the thyroid gland synthesize, store, and secrete calcitonin (thyrocalcitonin). These cells are derived from neural crest cells that fuse with the thyroid gland.

What are C cells in the body?

Parafollicular cells, also called C cells, are neuroendocrine cells in the thyroid. The primary function of these cells is to secrete calcitonin. They are located adjacent to the thyroid follicles and reside in the connective tissue.

What is the role of calcitonin in bone deposition?

Calcitonin: A hormone produced by the thyroid gland that lowers the levels of calcium and phosphate in the blood and promotes the formation of bone. Bone is in a constant state of remodeling. Calcitonin inhibits bone removal by the osteoclasts and at the same time promotes bone formation by the osteoblasts.

What are the target cells of thyroxine?

Once in the bloodstream, thyroxine travels to the organs, like the liver and kidneys, where it is converted to its active form of triiodothyronine. Thyroxine plays a crucial role in heart and digestive function, metabolism, brain development, bone health, and muscle control.

What are Dnes cells?

APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. These cells share the common function of secreting a low molecular weight polypeptide hormone.