What is PC disease?

What is PC disease?

Pachyonychia Congenita (PC) is an ultra-rare genetic autosomal dominant skin disorder. PC is caused by a mutation in one of five keratin genes KRT6A, KRT6B, KRT6C, KRT16 or KRT17.

Is Pachyonychia congenita curable?

Like most genodermatoses, no specific treatment or cure is known for pachyonychia congenita. Therapy is generally directed towards symptomatically improving the most bothersome manifestations of the disease and, because of the rarity of pachyonychia congenita, is based largely on anecdotal findings.

What does Pachyonychia mean?

: extreme usually congenital thickness of the nails.

Is Pachyonychia congenita contagious?

IS PC CONTAGIOUS? No. PC is not contaigious. You cannot ‘catch’ PC.

Is PC a disease?

Pachyonychia congenita (PC) is a rare inherited condition that primarily affects the nails and skin. The fingernails and toenails may be thickened and abnormally shaped.

What causes Trachyonychia?

In our experience, a majority of cases of trachyonychia referred to the nail clinic are idiopathic. However, trachyonychia has been associated with a number of dermatologic and nondermatologic diseases, and the most frequent associations are with alopecia areata/universalis, psoriasis, and lichen planus (table 2a, b).

What does Pachyonychia congenita look like?

Pachyonychia congenita is characterised by thickened skin of the palms and soles, thickened nails, and white patches in mucous membranes. The specific features depend on which keratin gene is affected.

What body systems does Pachyonychia congenita affect?

Pachyonychia congenita (PC) is a rare, autosomal dominant keratin disorder that typically affects the nails and palmoplantar skin, and often the oral mucosa, tongue, larynx, teeth, and hair.

What is vohwinkel syndrome?

Vohwinkel syndrome is a disorder with classic and variant forms, both of which affect the skin. In the classic form of Vohwinkel syndrome, affected individuals have thick, honeycomb-like calluses on the palms of the hands and soles of the feet (palmoplantar keratoses) beginning in infancy or early childhood.

What is Clouston syndrome?

Clouston syndrome is a form of ectodermal dysplasia, a group of about 150 conditions characterized by abnormal development of some or all of the ectodermal structures, which include the skin, hair, nails, teeth, and sweat glands.

Where did Pachyonychia congenita come from?

Pachyonychia congenita is caused by a mutation in one of five keratin genes, KRT6A, KRT6B, KRT6C, KRT16 or KRT17. These mutations are inherited in an autosomal dominant manner, although approximately 30-40% of cases are the result of new spontaneous mutations with no previous family history.

Are calluses genetic?

Callus formation is under genetic regulation, and consequently, a molecular understanding of this process underlies successful generation for propagation materials and/or introduction of genetic elements in experimental or industrial applications.

What kind of game is disorder on PC?

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What are the different types of PC disease?

The specific gene and specific mutation involved affects the disease condition for the PC patient. These different types of PC are properly classified as PC-K6a, PC-K6b, PC-K6c, PC-K16 and PC-K17 (related to the affected keratin gene where the mutation is located).

Which is the best definition of computer addiction?

What is Computer Addiction? Computer addiction is defined as the persistent, compulsive use of a computer despite negative consequences. Those who suffer from computer addiction tend to prioritize computer use above all other daily activities and responsibilities.

How does computer addiction affect your mental health?

Computer addiction may increase your risk for developing a substance use disorder due to the way computer addiction can affect your physical, mental, and emotional well-being.