Table of Contents
What is meant by lead compound?
(leed KOM-pownd) In medicine, a chemical compound that shows promise as a treatment for a disease and may lead to the development of a new drug. Thousands of compounds are tested in the laboratory to find a lead (“leading”) compound that may act on specific genes or proteins involved in a disease.
What compounds contain lead?
The major soluble lead compounds are lead acetate, lead acetate trihydrate, lead chloride, lead nitrate, and lead subacetate; all are sol- uble in water, and lead acetate trihydrate is miscible with water.
How is lead compound formed?
Lead occurs naturally in the earth’s crust. It is also found in combined form in several minerals: galena, anglesite, pyromorphite and mimetite. Lead may be released as particles into the atmosphere or as dissolved compounds in water. Lead is also released from natural sources such as windblown dusts and forest fires.
What are the properties of a good lead compound?
It must bind selectively to the receptor site on the target and elicit the desired functional response from the target molecule. It must have sufficient bioavailability and distribution within the body to reach the receptor site, and it must elicit the desired responses in vivo, in animal models of the human disease.
What is lead and lead compounds?
A lead compound (/ˈliːd/, i.e. a “leading” compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires …
What is lead medical term?
1. An electrical conductor carrying current or intermittent signals between an organ or tissue and an electrical or electronic device. 2. The tracing obtained from a particular combination of electrode positions.
Is lead a compound element or mixture?
Pure Substances
| Pure Substance | Element or Compound? | Consists of: |
|---|---|---|
| Lead (Pb) | element | lead atoms |
| Oxygen gas (O2) | element | oxygen molecules* |
| Water (H2O) | compound | water molecules |
| Ammonia (NH3) | compound | ammonia molecules |
How do you identify lead compound?
Lead compounds are found by characterizing natural products, employing combinatorial chemistry, or by molecular modeling as in rational drug design. Chemicals identified as hits through high-throughput screening may also become lead compounds.
Is lead a Prop 65 chemical?
Lead is on the Proposition 65 list because it can cause birth defects or other reproductive harm. Exposure to lead can harm the reproductive systems of men and women. Lead and lead compounds also are on the Proposition 65 list because they can cause cancer. Exposure to lead and lead compounds may increase cancer risk.
Which is the best description of a lead compound?
A lead compound (/ˈliːd/, i.e. a “leading” compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires modification to fit better to the
What can you use with lead in it?
Lead-acid batteries used in motorized equipment and vehicles such as cars, trucks, motorcycles, and boats. Lead fishing sinkers and curtain weights. Some candies and spices from Mexico and Asia, some balsamic vinegars, some brightly colored traditional remedies such as azarcon and greta, and some dietary supplements.
What is a lead compound in drug discovery?
Lead compound. A lead compound (i.e. a “leading” compound, not to be confused with various compounds of the metallic element lead) in drug discovery is a chemical compound that has pharmacological or biological activity likely to be therapeutically useful, but may nevertheless have suboptimal structure that requires modification…
Why are lead compounds sometimes called developmental compounds?
Lead compounds are sometimes called developmental candidates. This is because the discovery and selection of lead compounds occurs prior to preclinical and clinical development of the candidate.