What causes lipemic blood sample?

What causes lipemic blood sample?

The most common cause of lipemia is nonfasting, with recent ingestion of lipid-containing meal. More severe lipemia results from a disease condition causing hypertriglyceridemia (eg, diabetes, genetic hyperlipidemia) or recent intravenous infusion of a lipid emulsion.

What are two reasons for a lipemic specimen?

After hemolysis, lipemia is the most frequent endogenous interference that can influence results of various laboratory methods by several mechanisms. The most common preanalytical cause of lipemic samples is inadequate time of blood sampling after the meal or parenteral administration of synthetic lipid emulsions.

What does it mean when labs are Hemolyzed?

The term hemolysis designates the pathological process of breakdown of red blood cells in blood, which is typically accompanied by varying degrees of red tinge in serum or plasma once the whole blood specimen has been centrifuged.

What does it mean when a blood sample is lipemic?

Lipemia is presence of a high concentration of lipids (or fats) in the blood. When donated blood is lipemic it causes the plasma-containing products to have a milky appearance.

What can cause a blood specimen to become Hemolyzed?

Hemolysis resulting from phlebotomy may be caused by incorrect needle size, improper tube mixing, incorrect filling of tubes, excessive suction, prolonged tourniquet, and difficult collection.

What is dog lipemia?

Lipemia can be defined as the turbidity caused by lipoprotein accumulation in a blood sample (Kazmierczak 2013). The normal pale-colored canine serum usually has a triglyceride (TG) concentration of less than 200 mg/dL, whereas the “cloudy” serum contains around 300 mg/dL of TG.

What about lipemic blood What effect does this sample have on results?

Lipemia interferes with hematology tests by the following mechanism by light scattering. This affects the following results: Hemoglobin and hemoglobin-related indices: Results in falsely increased absorbance readings of hemoglobin, causing a falsely high measurement.

What causes a Hemolyzed blood sample?

Why do blood samples get Hemolyzed?

Hemolysis may be due to specimen collection, processing, or transport. Hemolysis may also be due to pathological conditions, such as immune reactions, infections, medications, toxins and poisons, and therapeutic procedures. Frequently, laboratory testing can still be performed on a hemolyzed sample.

Why is hemolysis of a blood specimen such an issue with lab testing?

The hemolysis can cause a false elevation in some analytes, such as potassium and lactate dehydrogenase (LD), due to their high concentration in the red cell. The red or pink color of a hemolyzed sample can also interfere with some test methodologies, such as spectrophotometric methods.

What is lipemic or Lactescent specimen?

Lipemia. Lipemia (lactescence) is caused by increased triglycerides (usually as chylomicrons and infrequently from high concentrations of very low density lipoproteins).

What causes Lipemic in dogs?

The most common disorders in dogs that result in this type of fasting lipemia are diabetes mellitus, hyperadrenocorticism, and pancreatitis. Corticosteroid therapy can also result in this type of a fasting lipemia. High triglycerides and cholesterol would be seen on a chemistry panel.

How are blood tests affected by hemolyzed samples?

Tests Affected by Hemolyzed, Lipemic and Icteric Samples And Their Mechanism. Interferences from hemolysis, lipemia and icterus are most frequently noted which alter the assay results.

Why are so many hemolyzed specimens in the Ed?

Although hemolyzed specimens may reflect the presence of hemolytic anemia, in most cases they are due to preanalytical sources related to incorrect procedures or failure to follow procedures for collection, handling and storage of the samples; some of these are typical of the ED.

How are hemolyzed, lipemic and icteric samples affected?

Tests Affected by Hemolyzed, Lipemic and Icteric Samples And Their Mechanism. When a substance or process falsely alters the test results, it may lead to inappropriate further tests, incorrect diagnosis and treatments with potentially unfavourable outcomes for the patient.

How does lipemia affect results of laboratory tests?

This mechanism is probably the most common way in which lipemia affects results of laboratory tests. Lipoprotein particles in the sample can absorb light. The amount of absorbed light is inversely proportional to the wavelength and decreases from 300 to 700 nm, with no specific absorption peaks in between (22).